Epistemonikos, developed by the Epistemonikos Foundation, is a database of systematic reviews in healthcare that includes over 125,000 systematic reviews and over 315,000 studies that are included in those reviews. It is a collaborative, multilingual database of research evidence. It was developed and is maintained by systematically searching electronic databases and other sources for relevant systematic reviews and broad syntheses of reviews. The aim of Epistemonikos is to provide rapid access to systematic reviews in health. A unique feature of Epistemonikos is that it links together systematic reviews, broad syntheses of reviews and primary studies, thus providing a highly efficient method for searching [Rada 2013]. In addition, it includes translations of the titles and abstracts of included records to facilitate searching in different languages and it is continually updated by searching multiple sources of systematic reviews and broad syntheses of reviews.

Epistemonikos gathers information from multiple sources of systematic reviews, broad syntheses of reviews and structured summaries. Primary studies in Epistemonikos include all the studies that met the inclusion criteria for the systematic reviews in Epistemonikos. The only limitations for inclusion of primary studies in Epistemonikos are those that were established by the review authors.

Epistemonikos uses machine translation, crowdsourcing, and collaborative translation to provide all the information in different languages, including: Arabic, Chinese, Dutch, English, French, German, Italian, Portuguese and Spanish.